Frank McGlynn, who has recovered from a hamstring injury, has failed to force his way back into the team.
Dermot Molloy, who scored 0-2 as a substitute against Cavan, and Michael Hegarty are on the bench.
Teenage sensation Patrick McBrearty and Colm McFadden are listed alongside Murphy in the full-forward line, with Mark McHugh, who operated in the corner against Cavan, named at centre-forward.
Said Jim: “We know Tyrone are a formidable challenge. Along with Armagh, they have been the top team in Ulster for over a decade.
“They are a very experienced side with multiple All-Ireland winners in their team. We know what we are up against and we have prepared as well as we can.
“All we can do is focus on our own game and get ourselves right and go out and produce our best on the day and hope it is good enough.”
The winners of Sunday’s tie will meet Derry in the Ulster final at Clones in three weeks’ time. The losers will enter the All-Ireland qualifiers on Saturday, July 9.
DONEGAL (SFC v Tyrone): Paul Durcan; Karl Lacey, Neil McGee, Paddy McGrath; Kevin Cassidy, Anthony Thompson, Marty Boyle; Rory Kavanagh, Kevin Rafferty; Martin McElhinney, Mark McHugh, Ryan Bradley; Colm McFadden, Michael Murphy (capt), Patrick McBrearty.
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